Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea: Role of Symptom Subtypes
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY
The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 75
Healthy Volunteers: f
View:
• 30 to 75 years of age
• Among patients with hypertension, no change in BP medication for at least 3 months.
• Willing and able to give informed consent
• Willing and able to complete ambulatory blood pressure monitoring at baseline and after 6-months.
• Sleep study \[Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) performed based on clinical grounds
• 4% oxygen desaturation index (ODI4) ≥15 events/hour on clinical sleep study
• Planned CPAP treatment by treating provider
Locations
United States
Ohio
Martha Morehouse Medical Pavilion, Suite 2600
RECRUITING
Columbus
Contact Information
Primary
ALICIA GONZALEZ ZACARIAS, MD
Alicia.Gonzalezzacarias@osumc.edu
614-366-2361
Time Frame
Start Date: 2021-03-22
Estimated Completion Date: 2032-03-01
Participants
Target number of participants: 1739
Treatments
OSA Subjects Treated with CPAP
Patients with moderate to severe OSA (ODI4\>15/h) who accept CPAP therapy.
Related Therapeutic Areas
Sponsors
Collaborators: The University of Western Australia, University of Iceland, Ruijin Hospital, Charite University, Berlin, Germany, University of Sydney, National University of Singapore, Peking University, Chang Gung Memorial Hospital, Geisinger Health, University of Pennsylvania
Leads: Ohio State University